Phialophora verrucosa
Colonies (SDA) are slow growing, initially dome-shaped, later becoming flat, suede-like and olivaceous to black in colour. Phialides are flask-shaped or elliptical with distinctive funnel-shaped, darkly pigmented collarettes. Conidia are ellipsoidal, smooth-walled, hyaline, mostly 3.0-5.0 x 1.5-3.0 μm, and aggregate in slimy heads at the apices of the phialide. RG-2 organism.
Culture of Phialophora verrucosa.
Phialides and conidia of P. verrucosa.
Phialides and conidia of P. verrucosa.
MIC data is limited. Antifungal susceptibility testing of individual strains is recommended.
| Antifungal | MIC ug/mL |
Antifungal | MIC ug/mL |
Antifungal | MIC ug/mL |
Range |
Range |
Range |
|||
| Amphotericin B | 0.3-4 |
Itraconazole | 0.03-0.06 |
Voriconazole | 0.3-0.5 |
Clinical significance:
Phialophora verrucosa is a well documented causative agent of chromoblastomycosis, and mycetoma. It produces characteristic flask-shaped phialides with distinctive funnel-shaped, darkly pigmented collarettes. Environmental isolations have been made from plant debris, wood piles, fence posts, tree stumps, soil and animal faeces.
Mycosis: Chromoblastomycosis
Further reading:
Kwon-Chung, K.J. and J.E. Bennett. 1992. Medical Mycology. Lea & Febiger, Philadelphia and London.
Domsch, K.H., W. Gams, and T.H. Anderson. 1980. Compendium of soil fungi. Volume 1. Academic Press, London, UK.
MIC data is limited. Antifungal susceptibility testing of individual strains is recommended.
| Antifungal | MIC ug/mL | Antifungal | MIC ug/mL |
||
Range |
MIC90 |
Range |
MIC90 |
||
| Itraconazole | 0.03-0.5 |
0.5 |
Amphotericin B | 0.06-4 |
1 |
| Voriconazole | 0.03-0.5 |
0.25 |
Posaconazole | 0.06-0.5 |
0.25 |
Mycosis: Chromoblastomycosis
Further reading:
De Hoog G.S. and J Guarro. 1995. Atlas of clinical fungi. Centraalbureau voor Schimmelcultures, Baarn and Delft, The Netherlands.
Kwon-Chung, K.J. and J.E. Bennett. 1992. Medical Mycology. Lea & Febiger, Philadelphia and London.
