Cladophialophora carrionii
Synonym: Cladosporium carrionii
Colonies are slow growing, reaching 3-4 cm in diameter after one month, with a compact suede-like to downy surface and are olivaceous-black in color.
Culture of Cladophialophora carrionii.
Microscopy shows ascending to erect, olivaceous-green, apically branched, elongate conidiophores producing branched acropetal chains of smooth-walled conidia. Conidia are pale olivaceous, smooth-walled or slightly verrucose, limoniform to fusiform, 1.5-3.0 x 2.0-7.0 µm in size. Bulbous phialides with large collarettes and minute, hyaline conidia are occasionally formed on nutritionally poor media. Maximum growth temperature 35-37C. RG-2 organism.
Conidiophores and conidia of C. carrionii.
Key Features: conidia are smaller and comprise heavily branched systems which fall apart much more easily than in the other Cladophialophora species.
MIC data is limited. Antifungal susceptibility testing of individual strains is recommended.
| Antifungal | MIC ug/mL | Antifungal | MIC ug/mL |
||
Range |
MIC90 |
Range |
MIC90 |
||
| Itraconazole | 0.03-0.5 |
0.5 |
Amphotericin B | 0.06-4 |
1 |
| Voriconazole | 0.03-0.5 |
0.25 |
Posaconazole | 0.06-0.5 |
0.25 |
Clinical significance:
Cladophialophora carrionii is a recognized agent of chromoblastomycosis and it has been isolated from soil and fence posts made from Eucalyptus sp. Cases of chromoblastomycosis caused by C. carrionii are commonly found in Australia, Venezuela, Madagascar and South America. Isolates from phaeomycotic cysts and opportunistic infections have also been reported.
Mycosis: Chromoblastomycosis
Further reading:
De Hoog G.S. and J Guarro. 1995. Atlas of clinical fungi. Centraalbureau voor Schimmelcultures, Baarn and Delft, The Netherlands.
Kwon-Chung, K.J. and J.E. Bennett. 1992. Medical Mycology. Lea & Febiger, Philadelphia and London.
