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School of Molecular & Biomedical Science
The University of Adelaide
AUSTRALIA 5005

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Dr David Ellis
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Cladophialophora bantiana

Synonyms: Xylohypha bantiana; Cladosporium bantianum; Cladosporium trichoides.

Colonies are moderately fast growing, olivaceous-grey, suede-like to floccose and grow at temperatures up to 42-43C. Conidia are formed in long, sparsely branched, flexuous, acropetal chains from undifferentiated conidiophores. Conidia are one-celled (very occasionally two-celled), pale brown, smooth-walled, ellipsoid to oblong-ellipsoid and are 2-3 x 4-7 um in size.

Conidiophore and conidia
Conidiophore and conidia of Cladophialophora bantiana.

Cladophialophora bantiana may be distinguished from Cladosporium species by the absence of conidia with distinctly pigmented hila, the absence of characteristic shield cells and by growth at 42C (compared with Cladophialophora carrionii which has a maximum growth temperature of 35-36C).  RG-2 organism.

 

MIC data is limited.  Antifungal susceptibility testing of individual strains is recommended.

Antifungal MIC ug/mL Antifungal
MIC ug/mL
Range
MIC90
Range
MIC90
Itraconazole
0.03-0.5
0.5
Amphotericin B
0.06-2
0.5
Voriconazole
0.03-1
0.125
Posaconazole
0.008-0.06
0.06

Clinical significance:

Cladophialophora bantiana has been isolated from soil and is a recognized agent of cerebral phaeohyphomycosis. The fungus is neurotropic and may cause brain abscess in both normal and immunosuppressed patients.

Mycosis: Phaeohyphomycosis

Further reading:

De Hoog G.S. and J Guarro. 1995. Atlas of clinical fungi. Centraalbureau voor Schimmelcultures, Baarn and Delft, The Netherlands.

Kwon-Chung, K.J. and J.E. Bennett. 1992. Medical Mycology. Lea & Febiger, Philadelphia and London.