Acrophialophora fusispora
Colonies fast growing, greyish-brown with a black reverse. Conidiophores arising singly, terminally and laterally from the hyphae, erect, straight or slightly flexuose, tapering towards the apex, pale brown, rough-walled, up to 15 μm long, 2-5 μm wide, with whorls of phialides on the upper part. Phialides flask-shaped with a swollen base and a long, narrow neck, hyaline, smooth-walled or echinulate, 9-15 x 3-4.5 μm in the broadest part. Conidia in long chains, limoniform, one-celled, pale brown 5-12 x 3-6 μm, smooth to finely echinulate with indistinct spiral bands. Temperature: optimum 40C; maximum 50C.
Culture, phialides and conidia with striations of A. fusispora.
Key Features: hyphomycete with flask-shaped phialides producing long chains of one-celled, limoniform, pale brown conidia, with indistinct spiral bands.
MIC data is limited. Antifungal susceptibility testing of individual strains is recommended.
| Antifungal | MIC ug/mL |
Antifungal | MIC ug/mL |
Range |
Range |
||
| Itraconazole | 0.06-0.125 |
Amphotericin B | 0.25-2
|
| Voriconazole | 0.06 |
Posaconazole | 0.03 |
Clinical significance:
The genus Acrophialophora contains 3 species and is most commonly associated with soil, especially from India. A. fusispora is a rare human pathogen. RG-1 organism.
Mycosis: Phaeohyphomycosis
Further reading:
Domsch, K.H., W. Gams, and T.H. Anderson. 1980. Compendium of soil fungi. Volume 1. Academic Press, London, UK.
Rippon, J.W. 1988. Medical Mycology. 3rd Edition. W.B. Saunders Co., Philadelphia, USA.
